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Figure 1: Hypothetical model describing possible mechanism of TNF-α polymorphism leading to increased TNF-α expression on viral infection in DCM. In the case of wild type alleles at -238 and -863 position of TNF-α promoter gene as shown in Figure 1A, regulated production of TNF-α occurs after viral infection which may lead to the viral clearance but in the case of hosts having mutant alleles of TNF-α promoter gene i.e., 238GA and 863AA as shown in Figure 1B, after viral infection TNF-α over-expression may lead to disease progression to dilated cardiomyopathy

Figure 1: Hypothetical model describing possible mechanism of TNF-α polymorphism leading to increased TNF-α expression on viral infection in DCM. In the case of wild type alleles at -238 and -863 position of TNF-α promoter gene as shown in Figure 1A, regulated production of TNF-α occurs after viral infection which may lead to the viral clearance but in the case of hosts having mutant alleles of TNF-α promoter gene i.e., 238GA and 863AA as shown in Figure 1B, after viral infection TNF-α over-expression may lead to disease progression to dilated cardiomyopathy