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Year : 2016  |  Volume : 34  |  Issue : 3  |  Page : 346--349

Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan

PB Mal1, J Farooqi1, S Irfan1, MA Hughes2, E Khan1 
1 Department of Pathology and Laboratory Medicine, Section of Clinical Microbiology, Aga Khan University, Karachi - 74800, Pakistan
2 Department of Medicine, Division of Infectious Diseases, University of Virginia 22908, USA

Correspondence Address:
E Khan
Department of Pathology and Laboratory Medicine, Section of Clinical Microbiology, Aga Khan University, Karachi - 74800
Pakistan

We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.

How to cite this article:
Mal P B, Farooqi J, Irfan S, Hughes M A, Khan E. Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan.Indian J Med Microbiol 2016;34:346-349

How to cite this URL:
Mal P B, Farooqi J, Irfan S, Hughes M A, Khan E. Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan. Indian J Med Microbiol [serial online] 2016 [cited 2021 Mar 5 ];34:346-349
Available from: https://www.ijmm.org/article.asp?issn=0255-0857;year=2016;volume=34;issue=3;spage=346;epage=349;aulast=Mal;type=0