Indian Journal of Medical Microbiology Home 

Year : 1998  |  Volume : 16  |  Issue : 4  |  Page : 154--157

Testing pooled sera for HCV antibody : an economic consideration

S Christopher, PG Babu, P Abraham, T Subramaniam, R Pulimood, TJ John, S Ratnam 
 Department of clinical virology Christian Medical College Hospital, Vellore 632 004

Correspondence Address:
S Christopher
Department of clinical virology Christian Medical College Hospital, Vellore 632 004

ABSTRACT: The need for the screening of blood donors for hepatitis C virus antibody (anti-HCV) is increasingly being recognised in developing countries. However, it has not yet become the standard practice due to the high cost of anti-HCV testing. In an attempt to reduce the cost of testing, we evaluated the reliability of testing pooled sera. A total of twenty serum pools each containing two, three, five and ten sera were tested using a second generation anti-HCV test kit (Abbott Diagnostics, North Chicago, III). Each serum pool contained one anti-HCV positive serum of low, medium or high antibody content. All pools of two sera tested positive for anti-HCV, whereas pools of 3 or more sera were found to be unsatisfactory. This data showed pools of two sera can be tested reliably, and this approach would significantly reduce the cost of anti-HCV testing, without compromising on the sensitivity.

How to cite this article:
Christopher S, Babu P, Abraham P, Subramaniam T, Pulimood R, John T, Ratnam S. Testing pooled sera for HCV antibody : an economic consideration.Indian J Med Microbiol 1998;16:154-157

How to cite this URL:
Christopher S, Babu P, Abraham P, Subramaniam T, Pulimood R, John T, Ratnam S. Testing pooled sera for HCV antibody : an economic consideration. Indian J Med Microbiol [serial online] 1998 [cited 2020 Oct 26 ];16:154-157
Available from: https://www.ijmm.org/article.asp?issn=0255-0857;year=1998;volume=16;issue=4;spage=154;epage=157;aulast=Christopher;type=0