Indian Journal of Medical Microbiology Home 

Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 21--24

Suppressive Effect Of Chloroquine On Humoral Response Of Normal Rhesus Monkeys

Ram Naresh Prasad1, R. C Mahajan2, N. K Ganguly3, S. K Garg4 
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Correspondence Address:
Ram Naresh Prasad


Two groups of normal Rhesus monkeys were immunized with one ml of 50 percent suspension of sheep erythrocytes in normal saline of which one group was treated with chloroquine (20 mg/kg body weight) for 7 days. The directed plaque forming cells (PFC) was detected in peripheral blood of these animals. The number of PFC in chloroquine treated groups was significantly (P=001) lower than the control. It was concluded that the drug might act in autoimmune diseases by inhibiting the function of B-lymphocyte too. The inhibitory action of chloroquine on B cells may be beneficial during course of malaria infection by depressing the polyclonal activation of malarial mitogens.

How to cite this article:
Prasad R, Mahajan R, Ganguly N, Garg S. Suppressive Effect Of Chloroquine On Humoral Response Of Normal Rhesus Monkeys.Indian J Med Microbiol 1984;2:21-24

How to cite this URL:
Prasad R, Mahajan R, Ganguly N, Garg S. Suppressive Effect Of Chloroquine On Humoral Response Of Normal Rhesus Monkeys. Indian J Med Microbiol [serial online] 1984 [cited 2020 Nov 26 ];2:21-24
Available from: https://www.ijmm.org/article.asp?issn=0255-0857;year=1984;volume=2;issue=1;spage=21;epage=24;aulast=Prasad;type=0