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Year : 2020  |  Volume : 38  |  Issue : 3  |  Page : 440-443

Characterisation of colonisation properties of vaginal lactobacilli from healthy Indian women: Implications for identification of potential probiotic candidates

ICMR-National AIDS Research Institute, 73 G Block, MIDC, Bhosari, Maharashtra, India

Correspondence Address:
Dr. Arati Mane
Division of Microbiology, ICMR-National AIDS Research Institute, 73 G Block, MIDC, Bhosari, Maharashtra - 411 026
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmm.IJMM_20_108

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The ability of probiotic bacteria to colonise the target site is considered of utmost importance and used for preliminary screening of potential probiotic candidates. Thirty-eight vaginal Lactobacillus strains isolated from healthy women and characterised by 16S RNA sequencing were assessed for colonisation characteristics including adherence to human vaginal epithelial cells, auto-aggregation and hydrophobicity. No significant difference in adherence (P = 0.384), auto-aggregation (P = 0.282) and hydrophobicity (P = 0.084) abilities between Lactobacillus species was observed, however, significant difference in colonisation characteristics between strains of the same species was noted (P < 0.001). We identified seven Lactobacillus strains that may serve as best candidates for vaginal probiotic development.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04