| BRIEF COMMUNICATION |
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| Year : 2016 | Volume
: 34
| Issue : 3 | Page : 346-349 |
Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan
PB Mal1, J Farooqi1, S Irfan1, MA Hughes2, E Khan1
1 Department of Pathology and Laboratory Medicine, Section of Clinical Microbiology, Aga Khan University, Karachi - 74800, Pakistan
2 Department of Medicine, Division of Infectious Diseases, University of Virginia 22908, USA
Correspondence Address:
E Khan
Department of Pathology and Laboratory Medicine, Section of Clinical Microbiology, Aga Khan University, Karachi - 74800
Pakistan
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0255-0857.188338
We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.
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