| BRIEF COMMUNICATION |
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| Year : 2015 | Volume
: 33
| Issue : 4 | Page : 565-567 |
HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS
K Mohanakrishnan1, A Kasthuri2, SK Amsavathani3, G Sumathi1
1 Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India
2 Department of Community Medicine, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India
3 Department of Microbiology, Meenakshi Medical College and Research Institute, Enathur, Kanchipuram, Tamil Nadu, India
Correspondence Address:
K Mohanakrishnan
Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0255-0857.167326
This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).
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