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Year : 2014  |  Volume : 32  |  Issue : 3  |  Page : 315-317

Detection of Mycobacterium tuberculosis growth by direct microscopic observation has a lower cost, higher sensitivity and higher diagnostic value than liquid and solid media cultures

1 Departament of Bacteriology,Clinic of Pulmonary Diseases, Iasi, Romania
2 Department of Pathology, University of Medicine and Pharmacy "Gr.T.Popa", Iasi, Romania
3 Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy "Gr.T.Popa", Iasi, Romania
4 University of Agricultural Sciences and Veterinary Medicine, Iasi, Romania
5 Department of Pulmonary Diseases, University of Medicine and Pharmacy "Gr.T.Popa", Iasi, Romania

Correspondence Address:
B Grigoriu
Department of Pulmonary Diseases, University of Medicine and Pharmacy "Gr.T.Popa", Iasi, Romania

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Source of Support: CNCSIS: PN II-IDEI PCE 2011., Conflict of Interest: None

DOI: 10.4103/0255-0857.136585

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Background: Culture is needed to confirm tuberculosis but results are generally obtained after several weeks. Objectives: We compared a direct microscopic observation technique for detection of mycobacterial culture positivity (MODS) with the classic solid and MB/BacT cultures in terms of sensitivity, contamination rate, speed and cost on 488 samples. Results: The sensitivity of the MODS technique - 99,2% (162 positive samples) was higher than MB/BacT 78,4% (125 positive samples) and solid culture 69,6% (113 positive samples) P < 0.005 for all comparisons. The median times to positivity were 21, 13.3 and 3 days on solid media, B/BacT and MODS respectively. Conclusions: The MODS technique is faster and more sensitive than both solid media and MB/BacT culture.


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2004 - Indian Journal of Medical Microbiology
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