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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 32  |  Issue : 3  |  Page : 270-276

Association of MDR-TB isolates with clinical characteristics of patients from Northern region of India


1 Department of Microbiology, Institute of Medical Sciences, Uttar Pradesh, India
2 Department of Endocrinology and Metabolism, Institute of Medical Sciences, Uttar Pradesh; Department of Biochemistry, Chikka Muniyappa Reddy Institute of Management Studies, Bangalore, Karnataka, India
3 Department of Zoology and Centre for Genetic Disorder, Banaras Hindu University, Varanasi, Uttar Pradesh, India
4 Division of Biostatistics, Institute of Medical Sciences, Uttar Pradesh, India
5 Department of Endocrinology and Metabolism, Institute of Medical Sciences, Uttar Pradesh, India

Correspondence Address:
S Anupurb
Department of Microbiology, Institute of Medical Sciences, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.136561

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Purpose: We sought to determine the characteristics and relative frequency of transmission of MDR-TB in North India and their association with the clinical and epidemiological characteristics of TB-patients. Materials and Methods: To achieve the objectives PCR-SSCP, MAS-PCR and direct DNA sequencing were used against 101 Mycobacterium tuberculosis isolates. Results: Multidrug-resistant-TB isolates were found to be significantly higher (P = 0.000) in previously treated patients in comparison to newly diagnosed patients. Further, significant differences (P = 0.003) were observed between different age groups (Mean ± SD, 28.6 ± 11.77) of the TB patients and multidrug resistance. Most frequent mutations were observed at codons 531 and 315 of rpoB and katG genes, respectively, in MDR-TB isolates. Conclusion: Routine surveillance of resistance to anti-TB drugs will improve timely recognition of MDR-TB cases and help prevent further transmission in Northern India.






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2004 - Indian Journal of Medical Microbiology
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