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Year : 2013  |  Volume : 31  |  Issue : 2  |  Page : 138-141

Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina

1 Department of Clinical Microbiology, Laboratory of Molecular Application, Faculty of Medicine, Northeast National University, Corrientes, Argentina
2 Department of Virology, Laboratory of Molecular Biology, Institute of Regional Medicine, Northeast National University, Chaco, Argentina
3 Department of Virology, Oncogenic Virus Service, National Reference Laboratory on Human Papillomavirus, National Institute of Infectious Diseases "Carlos G. Malbrán", Buenos Aires, Argentina

Correspondence Address:
G D Deluca
Department of Clinical Microbiology, Laboratory of Molecular Application, Faculty of Medicine, Northeast National University, Corrientes
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0255-0857.115228

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Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.


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