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Year : 2012  |  Volume : 30  |  Issue : 4  |  Page : 403-406

Comparison of HIV-1 RNA level estimated with plasma and DBS samples: A pilot study from India (South)

Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu-632004, India

Correspondence Address:
R Kannangai
Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu-632004
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Source of Support: Authors like to thank Christian Medical College Fluid Research Fund for the partial financial support for this study, Conflict of Interest: None

DOI: 10.4103/0255-0857.103759

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Purpose: The use of dried blood spots (DBS) for HIV-1 viral load determination could greatly enhance the management of HIV infected individuals in resource-limited countries. Objective: To compare the HIV-1 viral load values obtained between parallel collected plasma and DBS. Materials and Methods: DBS and plasma samples were collected from 62 HIV-1 infected individuals and were used for determination of HIV-1 RNA concentrations using the Abbot real-time HIV-1 PCR. Result: Mean of the log difference of viral load values between plasma and DBS was -0.41 log. DBS viral load values significantly correlated with plasma viral load (r = 0.9818, P < 0.0001). Conclusion: These results suggest that DBS samples can be used as an alternative to plasma for the estimation of HIV-1 viral load if samples are appropriately stored.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04