| BRIEF COMMUNICATION |
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| Year : 2012 | Volume
: 30
| Issue : 1 | Page : 93-95 |
Carbapenem resistance among Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in south India
S Nagaraj1, SP Chandran2, P Shamanna1, R Macaden3
1 Department of Microbiology, St. Johns Medical College, Bangalore, India
2 Department of Microbiology, St. Johns Medical College, Bangalore; Infectious Disease Unit, St. Johns Research Institute, Bangalore - 560034, India
3 Infectious Disease Unit, St. Johns Research Institute, Bangalore - 560034, India
Correspondence Address:
R Macaden
Infectious Disease Unit, St. Johns Research Institute, Bangalore - 560034
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0255-0857.93054
Carbapenem resistance among clinical isolates of Enterobacteriaceae, especially Escherichia coli and Klebsiella pneumoniae, is largely conferred by metallo-β-lactamase (MBL). Fifty-one non repetitive isolates of carbapenem-resistant (Meropenem and Imipenem) E. coli and K. pneumoniae were studied to determine the molecular mechanism for resistance. Presence of blaNDM and blaVIM was determined by polymerase chain reaction (PCR) and DNA sequencing. blaNDM was detected from majority of carbapenem-resistant K. pneumoniae (75%) and E. coli (66.6%). Timely detection and appropriate and aggressive infection control measures are required to control the spread of these bacteria in healthcare settings.
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