| BRIEF COMMUNICATION |
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| Year : 2009 | Volume
: 27
| Issue : 1 | Page : 40-43 |
Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis
HH Akbulut1, F Deveci2, I Celik3, F Ilhan1, T Turgut2
1 Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
2 Department of Chest Diseases, Faculty of Medicine, Firat University, Elazig 23119, Turkey
3 Department of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Firat University, Elazig 23119, Turkey
Correspondence Address:
H H Akbulut
Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 19172058 
T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3 +/ gamma-delta (γδ) TCR+ and CD3 +/ alpha-beta (αβ) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3 + and CD3 +/αβ TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3 +/γδ and CD3+/αβ TCR+ were not statistically different between active and inactive PT patients. It was concluded that αβ TCR+ T cells might have a protective role in tuberculosis infection.
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