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Year : 2002  |  Volume : 20  |  Issue : 1  |  Page : 12-15

Correlation of autoimmune reactivity with hepatitis B and C virus (HBV and HCV) infection in histologically proven chronic liver diseases

1 Dept. of Immunology, Stanley Medical College, Chennai - 600 001, India
2 Dept. of Microbiology, Dr. ALM PGIBMS, Taramani, Chennai - 600 113, India
3 Dept. of Gastroenterology, Stanley Medical College & Government Stanley Hospital, Chennai - 600 001, India
4 Dept. of Gastroenterology, Madras Medical College & Government General Hospital, Chennai - 600 003, India

Correspondence Address:
S Shantha
Dept. of Immunology, Stanley Medical College, Chennai - 600 001
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Source of Support: None, Conflict of Interest: None

PMID: 17657016

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PURPOSE: To comprehensively study the possibility of autoimmune reactivity by hepatitis viruses B and C (HBV & HCV) in Indian chronic liver disease (CLD) patients. METHODS: One hundred and sixty histopathologically proven CLD cases and 100 matched controls were analysed for viral serology for HBV and HCV and autoimmune serology for antinuclear antibody (ANA), anti smooth muscle antibody (ASMA) and Liver kidney microsomal antibody (LKM) using standard immunofluorescence technique. RESULTS: 43.7% of cases were chronic hepatitis B while 16.2% were positive for HCV. CLD-B cases showed ANA positivity in 27.1% and ASMA positivity in 25.7%. CLD-C cases revealed 26.9%, 46.1% and 11.1% positivity for ANA, ASMA and LKM antibodies respectively. These rates and titres of autoantibodies were statistically significant (p=<0.02) when compared with that of controls. Conclusions: Based on the pattern of autoantibody positivity, it could be concluded that chronic HBV infection may induce autoimmune hepatitis (AIH) type I and chronic HCV infection might trigger AIH - Type II in Indian CLD cases.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04