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| Year : 1999 | Volume
: 17
| Issue : 2 | Page : 85-87 |
Concomitant high level resistance to penicillin and aminoglycosides in enterococci at Nagpur, Central India
VA Agarwal, YI Jain, AA Pathak
Department of Microbiology, Govt. Medical College, Nagpur (MS)
Correspondence Address:
VA Agarwal
Department of Microbiology, Govt. Medical College, Nagpur (MS)
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: A total of 150 enterococci were speciated (129 enterococcus faecalis, 21 E. faecium) and studied for their susceptibility to penicillin, aminoglycosides and vancomycin by the disc diffusion test and agar dilution method. High level penicillin resistance (HLPR) with minimum inhibitory concentration (MIC) - 200 gm/ml was found in 32 percent of the enterococci. High level aminoglycoside resistance (HLAR) with MIC - 2000 gm/ml was found in 12 percent, 38 percent and 24.7 percent enterococci for gentamicin, kanamycin and streptomycin respectively. Concomitant HLPR and HLAR was found in 16 percent of the enterococci. Low level vancomycin resistance (LLVR) with MIC - 16 gm/ml was also encountered only in 3.3 percent enterococci that were not associated with HLPR or HLAR. Emergence of enterococci with concomitant resistance to penicillin and aminoglycosides emphasizes the need for a more restricted use of antimicrobials.
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