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Year : 1998  |  Volume : 16  |  Issue : 3  |  Page : 118-120

Immunoblot reactivity in relation to human immunodeficiency virus disease progression

Dept. of Clinical Virology, Christian Medical College and Hospital, Vellore 632 004, India

Correspondence Address:
P Srikanth
Dept. of Clinical Virology, Christian Medical College and Hospital, Vellore 632 004
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Source of Support: None, Conflict of Interest: None

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ABSTRACT: The immunoblot band pattern of reactivity of 119 HIV-1 antibody positive3 subjects in different stages of HIV disease were studied. The intensity of antibody bands were graded as strong, faint or absent and 'Z' test of significance was done for comparison of band intensities between three clinical categories namely, asymptomatic but not AIDS and AIDS. The symptomatic but not AIDS category was associated with loss of strong reactivity to the gag gene products of p55 and p17. In addition to this, the loss of strong reactivity to p24 and to the pol gene products of p66, p51, and p31 were associated with AIDS. In India, in the centers with facilities for Western Blot testing, it can be used not only for diagnosing HIV infection, but also for monitoring HIV disease progression by carefully analysing the band pattern of reactivity.

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2004 - Indian Journal of Medical Microbiology
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