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Year : 1998  |  Volume : 16  |  Issue : 3  |  Page : 108-111

Detection of microfilaria carriers in bancroftian endemic area using the secretory acetylcholinesterase of setaria cervi microfilariae : a pilot study

Dept of Biochemistry, Faculty of Science, Institute of Medical Science, Banaras Hindu University, Varanasi-221005, India

Correspondence Address:
S Sharma
Dept of Biochemistry, Faculty of Science, Institute of Medical Science, Banaras Hindu University, Varanasi-221005
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Source of Support: None, Conflict of Interest: None

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ABSTRACT: The efficacy of the secretory acetylcholinesterase of microfilariae of bovine filarial parasite Setaria cervi for the detection of asymptomatic microfilaraemic carriers was evaluated in Wuchereria bancrofti infested endemic areas using ELISA. The affinity purified AChE when used as antigen in ELISA, the mean O.D. for asymptomatic sera was found to be 3.5 times higher as compared to the endemic normal human sera. This heterologous antigen showed marked specificity in ELISA for filarial infections only. The study carried out in two bancroftian endemic areas near Varanasi, displayed an immunological sensitivity of 94 percent and 96 percent in Sunderpur and Chiraigaon area, respectively. It appears that S. cervi AChE antigen could detect the asymptomatic microfilaraemic carriers for the seroepidemiological surveys.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04