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Year : 1998  |  Volume : 16  |  Issue : 1  |  Page : 4-11

HIV and hepatotropic viruses : interactions and treatments

Dept. of Infectious Diseases and Tropical Medicine, Ruchill Hospital, Glasgow G209NB

Correspondence Address:
Carron B Mc
Dept. of Infectious Diseases and Tropical Medicine, Ruchill Hospital, Glasgow G209NB

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: Human immunodeficiency virus (HIV) may interact directly or indirectly with concurrent infections to alter the natural history and treatment outcomes of both disease. At a molecular level, interactions between HIV and hepatitic viruses may potentiate HIV replication but clinical studies have been inconclusive. However, HIV appears to influence the natural history of infections with certain hepatitis viruses. In patients infected with HIV and hepatitis B virus (HBV), chronic HBV carriage is more common and HBV DNA levels are increased although hepatic necroinflammation is reduced. Infections with HIV and hepatitis C virus (HCV) or hepatitis D virus (HDV) results in a higher viral load of the hepatitis virus and greater liver cell damage. The antiviral effect of alpha-interferon in liver cells in reduced in patients with concurrent HIV infection. In a small study of HIV infected patients post liver transplantation survival was reduced and HIV progression was increased.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04