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| Year : 1998 | Volume
: 16
| Issue : 1 | Page : 29-30 |
Induction of resistance to ciprofloxacin and other fluoroquinolones in clinical and environmental isolates of pseudomonas aeruginosa
BS Nagoba, SR Deshmukh, BJ Wadher, UG Gude, AV Gomashe, PM Tumane
Department of Microbiology, M.I.M.S.R Medical College, Latur
Correspondence Address:
BS Nagoba
Department of Microbiology, M.I.M.S.R Medical College, Latur
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: An attempt was made to induce in vitro resistance to ciprofloxacin in clinical (04) and environmental (02) isolates of Pseudomonas aeruginosa (MIC 0.4 to 08 miu g ciprofloxacin/ml) by 14 serial passages through media containing increasing concentration of ciprofloxacin. This in vitro manipulation of strains resulted in increase of MIC of ciprofloxacin from 0.4 to 0.8 miu g/ml of original strains to 9.5 to 12.0 miu g/ml indicating development of resistance to ciprofloxacin and a major decrease in the zone diameters to norfloxacin, pefloxacin and ofloxacin indicating development of cross-resistance to these agents. Results indicate that induced resistance to ciprofloxacin can promote the development of resistance to other fluroquinolones. This suggests that caution should be exerted in the use of fluroquinolones for the treatment of pseudomonal infections.
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