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Year : 1993  |  Volume : 11  |  Issue : 3  |  Page : 226-230

Detection Of Virus-Like Particles In Uterine Cervical Carcinoma Cells By Electron Microscopy

Correspondence Address:
V Thankamani

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Source of Support: None, Conflict of Interest: None

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Eight samples of tumour tissues from clinically diagnosed and histopathologically proved cervical squamous cell carcinoma cases were examined by Electron microscopy. The ultrathin sections showed virus-like particles, enveloped and ranging from 170 - 250nm (app) in size. They were found to be intranucelar and some were cytoplasmic. Viral inclusion-like bodies occurred within the malignant cell nucleus. The tumour tissues showing (?) viral practices were positive for Herpes Simplex Virus type-2 antigens, Human papilloma virus antigens (common genus specific) and Herpes Simplex Virus type - 2 DNA, and, one contained HPV - 16 DNA sequences. The results suggest a strong association between uterine cervical cancer and HSV-2 and HPV viruses.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04