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Year : 1993  |  Volume : 11  |  Issue : 3  |  Page : 214-217

In Vitro Susceptibility Of Filamentous Fungi To Antifungal Agents



Correspondence Address:
Pankajalakshmi


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Antimycotic susceptibility testing of 25 clinical isolates of filamentous fungi were carried out against six antifungal drugs, viz. Ketoconazole, miconazole, econazole, itraconazole, naftifine and terbinafine agar dilution technique. Terbinafine was the most effective drug inhibiting 50% (MIC 50) of the isolates of Aspergillus sp., at a concentration of 0.1 pg/ml. The MIC 50s for econazole and itraconazole and MIC 90s for terbinafine were 0.5 pg/ml. The MIC 50s for naftifine and ketoconazole and MIC 90s for econazole were 1 pg/ml. Itraconzole and miconazole required 2.5 and 10 pg/ml respectively for inhibiting 90% of the isolates tested. For the hyalohyphomycetes, econazole was most inhibitory with an MIC range of 0.5 - 1 pg/ml, followed by itraconzole, terbinafine, ketoconazole and naftinife. The dematiaceous fungi also were more susceptible to econazle (MIC range 0.01-0.5 pg/ml) followed by itraconzole, ketoconazole, terbinafine and naftinfine. Miconazole was not effective against these two groups as its MIC 50s were 100 pg/ml. The zygomycetes were susceptibile only to econazole (MIC rang 0.1-5 pg/ml). The MIC 50s for ketoconazole and the other drugs were 10 and 100-1001 pg/ml.






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2004 - Indian Journal of Medical Microbiology
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