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| Year : 1993 | Volume
: 11
| Issue : 2 | Page : 124-130 |
Biological Activities Of Shigella Toxin(S)
Rupa Sehgal, D Panigrahi, N Nayak, N.K Ganguly, R Sehgal
Correspondence Address:
Rupa Sehgal
 Source of Support: None, Conflict of Interest: None  | Check |
Fifty clinical Shigella isolates were investigated for serotyping and pathogenic mechanisms. Shigella flexneri (72%) was the most frequent isolate with S.flexneri 3 as the predominant serotype. Enter toxin was detected in 58% (29/50) isolates by rabbit ileal loop test and in 64% (32/50) isolates by rabbit skin permeability test. These included toxin extracts from all four sero-groups. Vero cell cyto-toxicity was observed in all the 47 extracts tested. TCID50 values for S.dysenteriae toxin was 10 fold lower as compared to corresponding values for other serogroups. This higher level of cytotoxin produced by S.dysenteriae could be related to the documented greater frequency of severe diarrhoea and dysentery caused by it in comparison with other forms of shigellosis.
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