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| Year : 1992 | Volume
: 10
| Issue : 4 | Page : 260-264 |
Comparative In-Vitro Activities Of Five Antibacterial Agents On Aerobic Bacteria Isolated From External Eye Infections
H.N Madhavan, D Jayanthi, S Thirunavukkarasu
Correspondence Address:
H.N Madhavan
 Source of Support: None, Conflict of Interest: None  | Check |
Antibiotics for topical use in external ocular infections are usually fortified preparations having higher concentration of the drug than the minimum inhibitory concentration (MIC) for the infecting bacterium. Kirby-Bauer method based on MIC inhibition zone diameter relationship generally used in laboratories for drug sensitivity of an organism does not reveal the true results of a “resistant” bacterium to the fortified concentration of the antibiotic used. Therefore, in vitro antibacterial activities tp determine the MIC of framycetin, gentamycin, tobramycin, norfloxacin and ciprofloxacin (0.25-16 µg/ml) on 600 aerobic bacterial (472 gram positive and 128 gram negative) isolates of external ocular infection were tested by agar dilution method. Ciprofloxacin was the most active among the five drugs with MIC90 being 4µg/ml. High percentage of resistance to framycetin, gentamycin, tobramycin and to a lesser extent to norfloxacin was recorded. Disk diffusion method for antibiotic sensitivity test is therefore not applicable for the bacterial isolates from external ocular infection which are being treated with fortified drugs.
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