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Year : 1992  |  Volume : 10  |  Issue : 4  |  Page : 248-253

Prevalence Of Serum Antibodies To Lipopolysaccharide Of Shigella Dysentery Type 1 In Patients With Haemolytic Uremic Syndrome In Delhi

Correspondence Address:
K Kishore

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Source of Support: None, Conflict of Interest: None

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Serological evidence of infection with Shigella dysenteriae type 1 as well as other verotoxin producing bacteria (Escherichia coli 0 26, 2 III and 0 157) was sought in 28 children suffering from Haemolytic Uremic Syndrome: (HUS) 25 age and sex matched controls were also studied. An ELISA was developed for detection of anti Lipopolysaccharide antibodies in sera samples. Nineteen of the 28 HUS patients but none of the 25 controls reacted with the LPS antigens derived from Vero toxin producing bacteria. While 13 of these patients reacted against only one of the four LPS, six reacted with more than one LPS antigen from the verotoxin producing bacteria but not with LPS antigen from the non pathogenic E.coli NCTC 10418.paired sera, two to three weeks apart, could be obtained from 20 HUS patients. Fourteen of these patients had reacted in high titer in their acute phase serum. There was an increase in titre in one patient while another did not show any change, but in the convalescent of twelve patients there was a significant fall in titre.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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