Experimental Induction Of Cervical Carcinoma By Herpes Simplex Virus Type-2 In Rabbits : Gynaecological, Cytopathological And Immunological Evaluations.

M Elanchezhiyan; K Udayasankar; P Rajendran; S Subramanian; S.P Thyagarajan

Indian Journal of Medical Microbiology

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Year : 1992 | Volume : 10 | Issue : 2 | Page : 126-132

Experimental Induction Of Cervical Carcinoma By Herpes Simplex Virus Type-2 In Rabbits : Gynaecological, Cytopathological And Immunological Evaluations.

M Elanchezhiyan, K Udayasankar, P Rajendran, S Subramanian, S.P Thyagarajan

Correspondence Address:
M Elanchezhiyan

Source of Support: None, Conflict of Interest: None

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Evaluation of rabbits as experimental animal model for Herpes simplex virus type-2 (HSV-2) (HV-219 Strain) induced cervical carcinoma resulted in the development of a neoplastic condition in the form of leukoplakic patches only. On Papanicolaouâ€™s staining, these areas revealed intra-nuclear vacuolization. The production of leukoplakic changes correlated with increase in the antibody level against HSV-2.

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