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Year : 1991  |  Volume : 9  |  Issue : 4  |  Page : 193-201

Heat Labile Enterotoxin By Various Salmonellae

Correspondence Address:
Manish Pandya

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Source of Support: None, Conflict of Interest: None

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93 strains of Salmonella belonging to 5 different serovars namely S.typhimurium, S.senftenberg, S.bareilly, S.welteverden and S.newport isolated from fecal samples of patients suffering from gastroenteritis were studied for the production of enterotoxin. The enterotoxin production was detected by using CHO, Vero and HeLa cell lines. Out of 93 strains tested enterotoxin production was shown by 63 strains (67.74%) in CHO cell assay, 56 strains (60.21%) in Viro cell assay and 31 strains (33.33%) in HeLa cell assay. The enterotoxin was found to be heat labile as it lost all its activity on cell lines on heating at 60 degree centigrade for 30 minutes and at 100 degree centigrade for 15 minutes. The effect of Salmonella heat labile enterotoxin (S-LT) on CHO, Vero and HeLa cell lines was found to be reversible. S-LT was neutralized by monoclonal anticholera enterotoxin. CHO cell assay was found to be a more sensitive assay for detection enterotoxigenicity of 6 additional strain of S-typhimurium and 1 additional strain of S-bareilly which was not detected in other two cell lines.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04