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| Year : 1991 | Volume
: 9
| Issue : 1 | Page : 5-9 |
Clinico-Immunological Correlation In Vernal Conjunctivitis
Ashok Sharma, I. S Jain, N. K Ganguly, Amod Gupta, Rakesh Sehgal
Correspondence Address:
Ashok Sharma
 Source of Support: None, Conflict of Interest: None  | Check |
Althogh type-I hypersensitivity has been considered to play a major role in the aetiopathogensis of vernal conjunctivitis the exact role of tear and serum Immunohlonulin (IgE) in the diagnosis of disease is not certain. In an attempt to determine their role, tear and serum IgE estimations were done by Enzyme linked Immuno-assay (ELISA) in 54 patients of vernal conjunctivitis. Tear and serum IgE levels were significantly higher in patients as compared to controls. Five times more rise in tear IgE as compared to serum values, suggested local production of immunoglobulin E in the sub-conjunctival tissue in vernal conjunctivitis. Rise of tear IgE levels was more specific than serum IgE and showed positive correlation with the severity of symptoms.
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