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Year : 1991  |  Volume : 9  |  Issue : 1  |  Page : 16-21

Detection Of Mycobactrial Antigen In Cerebrospinal Fluid By Inhibition Enzyme Linked Immnosorbent Assay And Its Diagnostic Application In Tuberculous Meningitis



Correspondence Address:
Annamma Mathai


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Inhibition enzyme - linked immunosorbent assay (ELISA) was standardised for the estimation of mycobacterial antigen in cerebrospinal fluid (CSF) specimens. Of the 40 patients with a clinical diagnosis of tuberculous meningitis (TBM) the assay was found to be positive in 28 patients. In a control group of 42 patients with non-tuberculous neurological diseases the assay was negative. The assay showed a sensitivity of 70% and 100% specificity for tuberculous aetiology. The inhibition ELISA, for the detection of mycobacterial antigen in CSF holds definite diagnostic potential for TBM because of its specificity. The assay could be applied as an aid in the laboratory diagnosis of TBM particularly when standard bacteriological methods are negative for M. tuberculosis in CSF specimens.






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2004 - Indian Journal of Medical Microbiology
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