Indian Journal of Medical Microbiology IAMM  | About us |  Subscription |  e-Alerts  | Feedback |  Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Ahead of Print | Current Issue | Archives | Search | Instructions  
Users Online: 1493 Official Publication of Indian Association of Medical Microbiologists 
 ~   Next article
 ~   Previous article
 ~   Table of Contents

 ~   Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~   Citation Manager
 ~   Access Statistics
 ~   Reader Comments
 ~   Email Alert *
 ~   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded6    
    Comments [Add]    

Recommend this journal


Year : 1990  |  Volume : 8  |  Issue : 4  |  Page : 121-127

Epstein-Barr Virus And Rheumatoid Arthritis-Associated Nuclear Antigen (RANA) In Rheumatoid Arthritis : A Correlative Study

Correspondence Address:
R Latif

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

In an attempt to correlate Epstein-Barr Virus and rheumatoid arthritis-associated nuclear antigen (RANA) 87 rheumatoid arthritis (RA), 66 connective tissue disorder and 76 controls were analyzed for antibodies to RANA and antibodies of EBV. Besides screening them for rheumatoid factor by conventional Rose-Waaler and Latex methods, anti-RANA and anti-EBV were screened by an in house agar gel diffusion and ELISA methods respectively. Further correlation was also done by radioimmunoprecipitation. Anti-RANA prevalence was found to be 68.1% in RA when compared to 39.3% in other connective tissue disease and 22.3% in normals, Rheumatoid arthritis patients also showed a higher positivity of Anti EBV (75.8%) when compared to 50% in other arthritis and 47.3% in controls. The breakup analysis has shown a good correlation of anti-RANA and anti-EBV in seropositive group than in seronagative (P < 0.01). Rheumatoid factor positivity has also seen to be dependent on anti-RANA and anti-EBV positivity. Radioimmunoprecipitation study has also revealed the cross-reactivity of RANA and EBV. The above parameter has reasonably RANA as an EBV component.

[PDF Not available]*

Print this article     Email this article

2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04