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Year : 1990  |  Volume : 8  |  Issue : 3  |  Page : 78-83

Latex Agglutination Test For Rapid Diagnosis Of Typhoid Fever

Correspondence Address:
Iqbal R Kaur

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Source of Support: None, Conflict of Interest: None

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The efficacy of Latex agglutination test (LAT) in the rapid diagnosis of typhoid fever was studied in parallel with blood cultures on 38 clinically suspected cases (Gr.I). 10 febrile cases other than typhoid fever (Gr.II), and 10 aferbile healthy controls (Gr.III). Antigen detection was done on blood culture broths and sera. Antiserum against S. typhi 901 ‘O’ was used after absorption with S. paratyphi A and Esch. coli. Analysis of the data show that S. typhi was isolated in 73.7% of the Gr. I cases; antigen detection by LAT in these blood culture broths and sera was 92.9% and 75% respectively. In the 26.3% of Gr.I cases, where blood culture was negative for S. typhi but widal was positive, the antigen could be detected in 100% of the sera indicating thereby the better sensitivity of LAT as compared to blood culture. However in the Gr. II and Gr. III cases antigen could not be detected in any of the blood culture broths or sera except in sera of 2 cases of Gr. II, where Esch. coli was isolated from blood. LAT therefore stands a good promise as a rapid diagnostic test for typhoid fever.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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