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Year : 1990  |  Volume : 8  |  Issue : 1  |  Page : 26-32

The Difference In Total And Specific IgA In Duodenal Aspirates Of Patients Suffering From Giardiasis With Or Without Malabsorption

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P Saha

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Ninety three subjects with a mean age of 31.92 years were selected for the present study to detect total and Giardia specific IgA in serum and duodenal aspirates. History of pain abdomen was given by 94.44% subjects in group A (giardiasis without malabsocrpiton), 100% subjects in group B (giardiasis with malabsocrption) 100% subjects in group C (malabsocrption without giardiasis). Formol-ether concentration method of stool examination gave a significantly higher isolation rate (100%) as compared to direct smear (80.33%) examination (P>0.001). Overall cure rate with oral metronidazole was found to be 100 per cent. Malabsorption of fat, D-xylose and Vitamin B12 was observed in 88%, 48% and 24% respectively. No IgA deficiency was noted in sera of Giardia infected cases with or without malbsorption. Following infection the total IgA level in duodenal aspirates was low as compared to IgA level from aspirates of those suffering from malabsorption. This level came back to normal after treatment. Low level of specific serum IgA was noted in group A subjects as compared to other groups. Following treatment a significant rise in specific IgA was noted. Similarly, specific IgA in duodenal aspirates was extremely low in infected subjects without malabsorption and it showed recovery after treatment.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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