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Year : 1989  |  Volume : 7  |  Issue : 4  |  Page : 174-176

Antimalarial Antibody Profile In Thalassaemia Patients

Correspondence Address:
N. J Choudhury

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Source of Support: None, Conflict of Interest: None

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A Total of 112 thalassaemia major patients and 242 healthy voluntary blood donors were tested for antimalarial antibodies by indirect fluorescent antibody (IFA) and micro-ELISA tests. Significant level of antibody was found in 25 (22.32%) patients by IFA and in 48 (42.85%) by ELISA test. The number of thalassaemia patients showing antimalarial antibody by both the tests was significantly higher as compared to 242 controls (healthy blood donors) out of which 30 (12.39%) showed antimalarial antibody by IFA and 47 (19.42%) by ELISA (P<0.05 and p<0.01 respectively). ELISA detected significant levels of antimalarial antibodies in higher number of patients as well control as compared to IFA test. Higher incidence of antimalarial antibodies in thalassaemia patients probably is due to frequent exposures to malaria parasite through repeated transfusions.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04