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Year : 1989  |  Volume : 7  |  Issue : 4  |  Page : 134-139

Immunological Studies Of Pertussis Vaccine In Mice And Their Relation To Immunity

Correspondence Address:
V. K Gupta

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Source of Support: None, Conflict of Interest: None

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Development of humoral and cell mediated immune response (CMIR) after administration of pertussis vaccine were studied in mice with special reference to mouse protection. Two doses could protect 90% of mice on 7th day itself as compared to 50% protection after single dose immunization. High level of agglutinin has been shown to correlate well with higher level of protection. CMI response as measured by Macrophage Migration inhibition (MMI) appeared after 14-21 days of immunization and rose in graded manner and reached to a peak on 56 day and also showed no sign of wanning. Cells transferred from donor mice receiving 2 doses of vaccine could protect 20-30% of normal recipient mice when transferred between 7-28 post immunization days (PID) and also transferred CMIR. These findings indicated possible role of CMI in pertussis during the part of infection, when agglutinin titre starts declining.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04