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Year : 1988  |  Volume : 6  |  Issue : 4  |  Page : 297-301

In Vitro Evaluation Of Metronidazole And Tinidazole On Strains Of Trichomonas Vaginalis



Correspondence Address:
Nancy Malla


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Source of Support: None, Conflict of Interest: None


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Thirty two strains of Trichomonas vaginalis isolated from symptomatic and asymptomatic subjects attending obstetrics and Gynaecology Out Patients Department and Family Welfare Clinic Of Nehru Hospital, attached to Postgraduate Institute of Medical Education and Research, Chandigarh were subjected to sensitivity tests against metronidazole and tinidazole in vitro. The minimum inhibitory concentrations for metronidazole and tinidazole respectively ranged from 0.312 ug/ml and 0.103 ug/ml to 0.555 ug/ml with small inoculum (50,000 parasites/ ml) and 0.625 ug/ml to 1.25 ug/ml and 0.555 ug/ml to 1.65 ug/ml with large inoculum (100,000 parasites/ml). The minimum lethal concentrations for metronidazole and tinidazole were found to be respectively 1.25 ug/ml to 2.5 ug/ml and 0.825 ug/ml to 3.3 ug/ml with small inoculum and 2.5 ug/ml to 3.75 ug/ml and 1.65 ug/ml to 3.3 ug/ml with large inoculum. No statistically significant difference was observed in sensitivity tests for freshly isolated strains and those maintained by serial subculturing as well as in strains isolated from symptomatic and asymptomatic subjects. There was 100 per cent correlation between the sensitivity of T vaginalisi n vitro and the clinical response to metronidazole. These results rule out in vitro resistance to metronidazole or tinidazole as the cause of therapeutic failures which may be encountered in this country.






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2004 - Indian Journal of Medical Microbiology
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