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Year : 1986  |  Volume : 4  |  Issue : 3  |  Page : 181-189

Profile Of Lymphocyte Number And Function During Experimental Pneumocystis Carinii Infection In Rats

Correspondence Address:
A Vohra

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Source of Support: None, Conflict of Interest: None

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The present study is an attempt to delineate the cellular immune response of pneumocystis carinii infected rats. It was observer that although B cells were decreased, but not adversely till the 5th week. The T-cell population was markedly decreased from second week onwards till the end of study (8 weeks). The lymphocytes of infected animals responded to phytohacmaggultinin (PHA), concanavalin A (Con-A) and P. carinii antigen. However, the response was significantly less (p<0.001) than in the normal animals. The inclusion of only protein fed and only steroid injected animal groups helped to understand the response. The low (8 percent) protein feeding to rats did not result in lowering of B cell percentage or blastogenic responses to PHA, Con-A and specific antigen, although T cells were decreased. Steroids had marked effect on all parameters and resulted in decrease of T and B cell percentage as well as blastogenic responses to various mitogens.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04