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Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 49-55

Development Of Cell-Mediated Immunity In Guinea Pigs Immunized With Ribonucleic Acid Protein Fraction Of Entamoeba Histolytica



Correspondence Address:
T Sundararaj


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The development of cell-mediated immunity at various time intervals was studied after immunization of guinea pigs with ribonucleic acid protein fraction (P-RNA) obtained from Enamoeba histolytica. The parameters for the study of cell-mediated immunity were delayed skin hypersensitivity (DH), macrophage migration (MMI) and macrophage aggregation (MA) elicited with P-RNA protein and lysate antigens from E. histolytica. Delayed hypersensitivity developed 14 days after immunization and persisted upto 60 days and in a few animals upto 90 days. Macrophage migration inhibition response with P-RNA antigen was more marked after 30 days of immunization. The response seen with other antigens were not much marked. Macrophage aggregation was prominent when elicited with P-RNA antigen and corresponded with MMI response.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04