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| Year : 1984 | Volume
: 2
| Issue : 1 | Page : 49-55 |
Development Of Cell-Mediated Immunity In Guinea Pigs Immunized With Ribonucleic Acid Protein Fraction Of Entamoeba Histolytica
T Sundararaj, A Sundararaj, S Subramanian
Correspondence Address:
T Sundararaj
 Source of Support: None, Conflict of Interest: None  | Check |
The development of cell-mediated immunity at various time intervals was studied after immunization of guinea pigs with ribonucleic acid protein fraction (P-RNA) obtained from Enamoeba histolytica. The parameters for the study of cell-mediated immunity were delayed skin hypersensitivity (DH), macrophage migration (MMI) and macrophage aggregation (MA) elicited with P-RNA protein and lysate antigens from E. histolytica. Delayed hypersensitivity developed 14 days after immunization and persisted upto 60 days and in a few animals upto 90 days. Macrophage migration inhibition response with P-RNA antigen was more marked after 30 days of immunization. The response seen with other antigens were not much marked. Macrophage aggregation was prominent when elicited with P-RNA antigen and corresponded with MMI response.
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