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Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 39-48

Evaluation Of Soluble Antigen Fluorescent Antibody (SAFA) Test In Laboratory Diagnosis Of Tuberculosis

Correspondence Address:
Om P Bhardwaj

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Source of Support: None, Conflict of Interest: None

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Modified Soluble Antigen Fluorescent Antibody (SAFA) test was employed to find its utility in laboratory diagnosis of tuberculosis. A total number of 166 sera, 51 from patients of tuberculosis and remaining from control subjects were studied. Over eighty two percent of the 51 sera from patients of pulmonary tuberculosis were strong reactors; in addition 8.5% were weak reactors. Serologic reactivity was found unrelated to the extent or duration of disease. Out of 115 control subjects, only 2 were strong reactors; one of these was from a tuberculin positive child with pyrexia of unknown origin while the other was from a healthy blood donor who was lost to follow up. The high degree of specificity of the test seems to be attributable to use of Mycobacterial Saline Extract (M.S.E.) as the antigen and sensitivity to the test system used.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04