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Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 21-24

Suppressive Effect Of Chloroquine On Humoral Response Of Normal Rhesus Monkeys

Correspondence Address:
Ram Naresh Prasad

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Source of Support: None, Conflict of Interest: None

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Two groups of normal Rhesus monkeys were immunized with one ml of 50 percent suspension of sheep erythrocytes in normal saline of which one group was treated with chloroquine (20 mg/kg body weight) for 7 days. The directed plaque forming cells (PFC) was detected in peripheral blood of these animals. The number of PFC in chloroquine treated groups was significantly (P=001) lower than the control. It was concluded that the drug might act in autoimmune diseases by inhibiting the function of B-lymphocyte too. The inhibitory action of chloroquine on B cells may be beneficial during course of malaria infection by depressing the polyclonal activation of malarial mitogens.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04