Indian Journal of Medical Microbiology IAMM  | About us |  Subscription |  e-Alerts  | Feedback |  Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Ahead of Print | Current Issue | Archives | Search | Instructions  
Users Online: 1220 Official Publication of Indian Association of Medical Microbiologists 
 ~   Next article
 ~   Previous article
 ~   Table of Contents

 ~   Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~   Citation Manager
 ~   Access Statistics
 ~   Reader Comments
 ~   Email Alert *
 ~   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal


Year : 1984  |  Volume : 2  |  Issue : 1  |  Page : 1-6

Essential Regions Of The Lipopolysaccharide Of Pseudomonas Aeruginosa Responsible For Ito Biological Activities

Correspondence Address:
Yuzuru J Homma

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Investigation of the relationship between the biological activities of the endotoxin of P. aeruginosa and chemical structure resulted in the dissociation of some of the biological activities of the endotoxin. Free lipid A was demonstrated to be responsible for the interferon-inducing activity, pyrogenicity and adjuvanticity. For manifesting inhibition of experimental tumor development or activation of proclotting enzyme of horseshoe crab (Tachypleus-tridentus), lipid A alone is not sufficient and a saccharide portion such as 3-deoxy-D-Manno-octulosonic acid is necessary to link the lipid A portion. That the polysaccharide portion plays a role in the activity of the complete lipopolysaccharide was also supported by the fact that chemical modification on the saccharide reduced the two activities drastically. Antitumor and interferon-inducing activities, adjuvanticity and activation of proclotting enzyme diminished by complete de-O-acylation by NH2 OH2 whereas interferon-inducing activity remained unchanged. Incomplete lipid A containing only amidelinked fatty acid is sufficient to induce interferon in vitro. None of the activities mentioned here was observed with degraded polysaccharide obtained after extraction of lipid A.

[PDF Not available]*

Print this article     Email this article

2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04