Indian J Med Microbiol Close
 

Figure 1: Schematic representation of excretion of Pro-drug and active colistin following administration of colistimethate Pharmacokinetic studies show that only 31% of the pro-drug was converted to active colistin even after 4 hours (slow conversion), resulting in the excretion of most of the pro-drug unchanged in urine

Figure 1: Schematic representation of excretion of Pro-drug and active colistin following administration of colistimethate Pharmacokinetic studies show that only 31% of the pro-drug was converted to active colistin even after 4 hours (slow conversion), resulting in the excretion of most of the pro-drug unchanged in urine