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Year : 2015  |  Volume : 33  |  Issue : 4  |  Page : 565--567

HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS

K Mohanakrishnan1, A Kasthuri2, SK Amsavathani3, G Sumathi1 
1 Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India
2 Department of Community Medicine, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India
3 Department of Microbiology, Meenakshi Medical College and Research Institute, Enathur, Kanchipuram, Tamil Nadu, India

Correspondence Address:
K Mohanakrishnan
Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu
India

This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).

How to cite this article:
Mohanakrishnan K, Kasthuri A, Amsavathani S K, Sumathi G. HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS.Indian J Med Microbiol 2015;33:565-567

How to cite this URL:
Mohanakrishnan K, Kasthuri A, Amsavathani S K, Sumathi G. HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS. Indian J Med Microbiol [serial online] 2015 [cited 2020 Aug 5 ];33:565-567
Available from: http://www.ijmm.org/article.asp?issn=0255-0857;year=2015;volume=33;issue=4;spage=565;epage=567;aulast=Mohanakrishnan;type=0