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Year : 2008  |  Volume : 26  |  Issue : 4  |  Page : 390--392

An unusual seroconversion profile in a pregnant woman infected with the human immunodeficiency virus-1: Need for using later generations HIV screening assays

R Kannangai1, AJ Kandathil1, HD Daniel1, S Prasannakumar1, J Lionnel2, P Abraham1 
1 Department of Clinical Virology, Christian Medical College, Vellore - 632 004, India
2 Department of Obstetrics and Gynaecology, Christian Medical College, Vellore - 632 004, India

Correspondence Address:
R Kannangai
Department of Clinical Virology, Christian Medical College, Vellore - 632 004
India

The first HIV-1 marker that appears in blood following infection is HIV-1 RNA and usually the load is in millions of copies/ ml preceding seroconversion. A 24-year-old pregnant woman, gravida 2, parity 1 was tested for HIV as part of antenatal screening. Three samples were collected and tested from this individual over a period 70 days. The HIV-1 RNA level during seroconversion phase was very low contrary to the well understood natural history of HIV infection. The reactivity rate in the ELISA and the Western Blot profile showed a gradual increase over the 70 days with a weak reactivity in a second generation assay (detects IgG only) for the third sample. This case illustrates the uncertainties regarding the serological window period in HIV infection and the need to use at least a third generation assay in testing centres for early detection of HIV infection.

How to cite this article:
Kannangai R, Kandathil A J, Daniel H D, Prasannakumar S, Lionnel J, Abraham P. An unusual seroconversion profile in a pregnant woman infected with the human immunodeficiency virus-1: Need for using later generations HIV screening assays.Indian J Med Microbiol 2008;26:390-392

How to cite this URL:
Kannangai R, Kandathil A J, Daniel H D, Prasannakumar S, Lionnel J, Abraham P. An unusual seroconversion profile in a pregnant woman infected with the human immunodeficiency virus-1: Need for using later generations HIV screening assays. Indian J Med Microbiol [serial online] 2008 [cited 2020 May 29 ];26:390-392
Available from: http://www.ijmm.org/article.asp?issn=0255-0857;year=2008;volume=26;issue=4;spage=390;epage=392;aulast=Kannangai;type=0