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Year : 2008  |  Volume : 26  |  Issue : 2  |  Page : 151--154

Genotypic resistance profile of HIV-1 protease gene: A preliminary report from Vellore, south India

AJ Kandathil1, R Kannangai1, OC Abraham2, TD Sudarsanam2, SA Pulimood3, G Sridharan1 
1 Department of Clinical Virology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
2 Department of Internal Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
3 Department of Dermatology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India

Correspondence Address:
R Kannangai
Department of Clinical Virology, Christian Medical College, Vellore - 632 004, Tamil Nadu
India

HIV-1 subtypes other than B are responsible for most new HIV infections worldwide; virus sequence data for drug resistance is described only from a limited number of non-B subtype HIV-1. This study is on mutations and polymorphisms of HIV-1 protease gene that can predict drug resistance in subtype C. The genotypic resistance assay was carried out on 38 HIV-1 strains with their plasma RNA and in nine, the proviral protease gene was sequenced. The treatment naοve strains showed minor resistance mutations, there were no major resistance mutations in the protease gene. We suggest the use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains.

How to cite this article:
Kandathil A J, Kannangai R, Abraham O C, Sudarsanam T D, Pulimood S A, Sridharan G. Genotypic resistance profile of HIV-1 protease gene: A preliminary report from Vellore, south India.Indian J Med Microbiol 2008;26:151-154

How to cite this URL:
Kandathil A J, Kannangai R, Abraham O C, Sudarsanam T D, Pulimood S A, Sridharan G. Genotypic resistance profile of HIV-1 protease gene: A preliminary report from Vellore, south India. Indian J Med Microbiol [serial online] 2008 [cited 2019 Dec 8 ];26:151-154
Available from: http://www.ijmm.org/article.asp?issn=0255-0857;year=2008;volume=26;issue=2;spage=151;epage=154;aulast=Kandathil;type=0