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Year : 2005  |  Volume : 23  |  Issue : 1  |  Page : 24--28

Safety and immunogenicity of the Intradermal thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine

Mala Chhabra1, RL Ichhpujani1, M Bhardwaj1, KN Tiwari2, RC Panda2, S Lal1 
1 National Institute of Communicable Diseases, Sham Nath Marg, New Delhi - 110 054, India
2 Municipal Corporation of Delhi, Delhi - 110 006, India

Correspondence Address:
Mala Chhabra
National Institute of Communicable Diseases, Sham Nath Marg, New Delhi - 110 054
India

PURPOSE: To test the immunogenicity of the WHO recommended DQ2-2-2-0-1-1DQ post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatment centers throughout India. METHODS: Purified chick embryo cell vaccine (PCECV) was administered in the dosage of 0.1mL per site to 53 Indian subjects. RESULTS: All subjects produced rabies antibodies above 0.5IU/mL by day 14 post-vaccination. Only minor adverse reactions including swelling (6.6%), erythema (5.4%) and pain (1.4%) were observed for which no treatment was required. CONCLUSIONS: This study demonstrated that PCECV is safe and highly immunogenic in Indian subjects when administered intradermally as 0.1mL/site using the DQ2-2-2-0-1-1DQ post-exposure regimen.

How to cite this article:
Chhabra M, Ichhpujani R L, Bhardwaj M, Tiwari K N, Panda R C, Lal S. Safety and immunogenicity of the Intradermal thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine.Indian J Med Microbiol 2005;23:24-28

How to cite this URL:
Chhabra M, Ichhpujani R L, Bhardwaj M, Tiwari K N, Panda R C, Lal S. Safety and immunogenicity of the Intradermal thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine. Indian J Med Microbiol [serial online] 2005 [cited 2020 Apr 2 ];23:24-28
Available from: http://www.ijmm.org/article.asp?issn=0255-0857;year=2005;volume=23;issue=1;spage=24;epage=28;aulast=Chhabra;type=0