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Year : 2003  |  Volume : 21  |  Issue : 3  |  Page : 213-

Role of anti-teichoic acid antibodies in the diagnosis of staphylococcus aureus infections using counterimmunoelectrophoresis

RP Dhale, CA Dharmadhikari, R DD Kulkarni, RM Powar 
 Department of Microbiology, Government Medical College, Miraj - 416 410, Maharashtra, India

Correspondence Address:
C A Dharmadhikari
Department of Microbiology, Government Medical College, Miraj - 416 410, Maharashtra
India

How to cite this article:
Dhale R P, Dharmadhikari C A, Kulkarni R D, Powar R M. Role of anti-teichoic acid antibodies in the diagnosis of staphylococcus aureus infections using counterimmunoelectrophoresis.Indian J Med Microbiol 2003;21:213-213

How to cite this URL:
Dhale R P, Dharmadhikari C A, Kulkarni R D, Powar R M. Role of anti-teichoic acid antibodies in the diagnosis of staphylococcus aureus infections using counterimmunoelectrophoresis. Indian J Med Microbiol [serial online] 2003 [cited 2019 Oct 23 ];21:213-213
Available from: http://www.ijmm.org/text.asp?2003/21/3/213/8023

Full Text

Dear Editor,

Ribitol teichoic acid is an important component of Staphylococcus aureus cell wall. It is antigenic and precipitating antibodies are produced by the patients in response to it.[1] Detection of anti-teichoic acid antibodies (ATA-Abs) by counterimmunoelectrophoresis (CIEP) can be useful and rapid method for the diagnosis of deep-seated Staphylococcus infections.[2]

This study included 136 cases of cellulitis, osteomyelitis, diabetic foot, burns etc. from Staphylococcal and other than Staphylococcus infections. ATA-Ab was detected by CIEP in 84 cases accounting for 61.8% incidence. Fifty control serum samples from healthy blood donors were included. From 39 culture proven S. aureus infections (87.00%), 11 cases showed titre of >4 (ATA-Ab). Thirty one of 43 (70.2%) cases of coagulase negative Staphylococcus infections showed low ATA-Ab titre (up to 2) and from 45 cases of other than Staphylococcus infections 12 cases (26.30%) showed very low titre of ATA-Ab. Low titre levels (1, 2) of teichoic acid antibody were found in patients with coagulase negative staphylococcal infections and other than staphylococcal infections caused by Enterobacteriaceae group of organisms.[2],[3] This may be because coagulase negative staphylococci contain very low proportion of glycerol teichoic acid with N-acetyl glucosamine residue as minor teichoic acid antigen. These minor antigens may induce antibodies against teichoic acid antigen in low titres. Thus ATA-Ab titre of >4 or greater by CIEP may be an additional diagnostic parameter in the diagnosis of S. aureus infections.[4],[5]

References

1Crowder, White JG. Teichoic acid antibodies in staphylococcal and non staphylococcal endocarditis; Annals of internal medicine 1972;77:87-90.
2Jackson SDR. Correlation of antistaphylococcal antibody titres with severity of staphylococcal disease. American J Med 1978;64:629-633.
3Le CT, Lewin DB. Teichoic acid serology in staphylococcal infections of infants and children. J Pediatr 1978; 93(4):572-577.
4Wise KA, Tosolini FA. Detection of Teichoic Acid antibodies in Staphylococcus aureus infections. Pathology 1992; 24(2):102-105.
5Tuazon SCV, John NTA. Antibodies in diagnosis of serious infection with S. aureus. Annals Int Med 1976;84(5): 543-546.