Studies of elimination of R-plasmids by triprolidine

K Roy, A Chakrabarti, A Sen, DP Acharya, A Roy 
 Department of Microbiology, Calcutta National Medical College, Calcutta,

Correspondence Address:
K Roy
Department of Microbiology, Calcutta National Medical College, Calcutta

ABSTRACT: We have reported recently on the wide spectrum of antibacterial activity of triprolidine, commonly marketed by the trade name actidil (R). Triprolidine, a broad spectrum antibacterial agent produces mutants under experimental selection procedures and these mutants develop cross-resistance to several other antibiotics. In this study of curing anti-plasmid effect on multiply antibiotic and triprolidine resistant bacterial, it was observed that elimination of R Plasmids was facilitated by the choice of optimal concentration of triprolidine. Significant elimination of single and combined antibiotic resistance occurred in S. aureus, E.coli and V.cholerae.