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 BRIEF COMMUNICATION
Year : 2020  |  Volume : 38  |  Issue : 2  |  Page : 210-212

Genomic evolution of severe acute respiratory syndrome Coronavirus 2 in India and vaccine impact


1 Division of Molecular Biology and Translational Bioinformatics, Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India
2 Hilda Lazarus Core Research Chair, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of General Medicine, Unit V, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Karthik Gunasekaran
Department of General Medicine Unit V, Christian Medical College, Vellore, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmm.IJMM_20_303

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Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.






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2004 - Indian Journal of Medical Microbiology
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