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Year : 2018  |  Volume : 36  |  Issue : 3  |  Page : 416-421

Changes in hepatitis C virus genotype distribution in chronic hepatitis C infection patients

1 Department of Medical Microbiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
2 Department of Infectious Diseases, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
3 Department of Medical Microbiology, Medical Faculty, Istanbul Bilim University, Istanbul, Turkey

Correspondence Address:
Dr. Mehmet Burak Selek
Department of Medical Microbiology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmm.IJMM_18_10

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Purpose: Identification of hepatitis C virus (HCV) genotypes is very important in the selection of antiviral treatment, dose adjustment of antiviral agents, determining the treatment duration and following-up of treatment response. We aimed to determine the distribution pattern of HCV genotypes in chronic hepatitis C infection (CHC) patients. Materials and Methods: We have included 106 CHC patients who were positive in the anti-HCV and HCV-RNA tests performed in our hospital during the 16-month period. Anti-HCV assays were performed on device using a chemiluminescent microparticle immunoassay, while HCV-RNA tests and HCV genotyping assays were performed by real-time polymerase chain reaction. Results: Of the 106 cases; genotype 1b was detected in 67.0%, genotype 3 was detected in 16.0%, genotype 1a was detected in 14.2% and genotype 2 was detected in 2.8% patients. Genotypes 4, 5 and 6 were not detected in our study group. There were no statistically significant differences between the gender and age groups according to the HCV genotype distribution. The genotype 3 detection rate (16%) was the highest rate among the studies compared with the other studies in our country. Conclusions: Events that cause social changes such as war and immigration and intense commercial and touristic activities affect and alter the HCV genotype distribution in HCV-infected patients. For this reason, further multicentre studies are required reflecting all the regions in order to determine the genotype distribution in HCV-infected patients at regular intervals.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04