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Year : 2015  |  Volume : 33  |  Issue : 5  |  Page : 61-66

The association between serum YKL-40 levels, mean platelet volume, and c-reactive protein in patients with cellulitis

1 Department of Infectious Disease, University of Recep Tayyip Erdogan, Rize, Turkey
2 Department of Internal Medicine, University of Recep Tayyip Erdogan, Turkey
3 Department of Biochemistry, University of Recep Tayyip Erdogan, Rize, Turkey
4 Department of Infectious Disease, Ataturk University, Erzurum, Turkey
5 Department of Thoracic Surgery, University of Recep Tayyip Erdogan, Rize, Turkey
6 Department of Radiology, University of Recep Tayyip Erdogan, Rize, Turkey

Correspondence Address:
A Erturk
Department of Infectious Disease, University of Recep Tayyip Erdogan, Rize
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0255-0857.150891

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Background: Lower limb cellulitis is an infectious disease that has serious complications unless it is treated. Objectives: In this pilot study, we evaluated whether levels of YKL-40, an acute-phase reactant, and mean platelet volume (MPV), which occurs secondary to inflammation in cellulitis, increase compared to healthy subjects. We also aimed to investigate the association between YKL-40 and MPV in the prognosis of the patients. Material and Methods: A total of 55 patients with cellulitis (23 men and 32 women) and a similar age group of 46 healthy individuals (22 men and 24 women) were included in the study. Cellulitis was diagnosed according to guideline. Serum YKL-40 levels, MPV, C-reactive protein (CRP), and other biochemical values of both groups were compared. Results: YKL-40 levels (52.2 ± 34.5 ng/mL vs 34.6 ± 18.0 ng/mL, P = 0.004), MPV (7.7 ± 1.0 fL vs 6.9 ± 0.7 fL, P < 0.001), and CRP (9.5 ± 8.2 mg/dL vs 0.7 ± 0.6 mg/dL, P < 0.001) were significantly higher in the patients with cellulitis than the control. The mean recovery time (RT) of the patients was 22.6 ± 6.9 days. We found that YKL-40 (odds ratio [OR] 0.1, confidence interval [Cl] 0.028-0.191, P = 0.009) and MPV (OR 2.4, Cl 0.254-4.578, P = 0.029) have an independent association with RT. Conclusion : YKL-40 and MPV values were correlated with higher CRP in the cellulitis group than in controls. According to these results, increased YKL-40 and MPV levels might be a prognostic factor for cellulitis in patients.


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2004 - Indian Journal of Medical Microbiology
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