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 BRIEF COMMUNICATION
Year : 2015  |  Volume : 33  |  Issue : 1  |  Page : 139-142

YnfA , a SMR family efflux pump is abundant in Escherichia coli isolates from urinary infection


1 Department of Pathology and Medicine, Sanjiban Hospital, Fuleswar, Howrah - 711 316, India
2 Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

Correspondence Address:
S M Mandal
Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.148415

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A quantitative study was undertaken to determine the expression level of different efflux pumps in multi-drug-resistant (MDR) Escherichia coli isolates from urinary infection. We have determined the presence of different efflux pumps and measured the expression level of tolC, mdfA, norE and ynfA genes among 48 isolates by quantitative real-time PCR. The expression level of tolC and ynfA was constantly high and observed among 75-80% of isolates, whereas mdfA and norE were expressed occasionally. Our findings suggest that ynfA, a new SMR efflux pump gene family member increases the antibiotics' resistance in E. coli.






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2004 - Indian Journal of Medical Microbiology
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